Gut-liver interactions in the IgA system.

H J Hodgson

doi:10.3109/00365528509093766

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Gut-liver interactions in the IgA system.

H J Hodgson

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Abstract

Recent experimental work in rodents has demonstrated that the liver can function as an 'IgA-pump', transporting polymeric IgA from serum to bile via a secretory-component mediated uptake at the surface of the hepatic parenchymal cell. Studies are surveyed which indicate that, although this process occurs in man, it is to a strikingly lesser degree, and interruption of this pathway does not explain the high serum IgA levels often seen in chronic liver disease: the explanation for this lies in enhanced synthesis of IgA, and diminished polymeric IgA catabolism unrelated to hepatobiliary transport.

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Animals Bile Digestive System Humans Hypergammaglobulinemia Immunoglobulin A Immunoglobulin A, Secretory Liver Liver Cirrhosis Liver Diseases Journal Article

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H J Hodgson. 1985. Gut-liver interactions in the IgA system.. https://doi.org/10.3109/00365528509093766

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