Corticotropin-releasing factor and behavior.

G F Koob; F E Bloom

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PubMed · 3871412

Corticotropin-releasing factor and behavior.

G F Koob·F E Bloom

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Abstract

Corticotropin-releasing factor (CRF) has behavioral activating effects when injected intracerebroventricularly in rats. CRF dose-dependently increased activity in a familiar photocell cage environment. This activation persisted after hypophysectomy, opiate receptor blockade, and low-dose dopamine receptor blockade, which suggests a unique mechanism of action. CRF also improved acquisition of a visual discrimination task. In aversive situations such as an open field test CRF produced behavioral changes consistent with increased emotionality. These results suggest that CRF liberated directly into the central nervous system may have a neurotropic action important for mobilizing behavioral responses to stress.

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Amygdala Animals Arousal Behavior, Animal Brain Corticotropin-Releasing Hormone Dose-Response Relationship, Drug Electroencephalography Hippocampus Hypophysectomy Injections, Intraventricular Learning Macaca mulatta Motor Activity Rats Journal Article Research Support, U.S. Gov't, P.H.S.

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G F Koob, F E Bloom. 1985. Corticotropin-releasing factor and behavior.. https://pubmed.ncbi.nlm.nih.gov/3871412/

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