Cholinergic involvement in lateral hypothalamic rewarding brain stimulation.

J S Yeomans; O Kofman; V McFarlane

doi:10.1016/0006-8993(85)90508-6

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Cholinergic involvement in lateral hypothalamic rewarding brain stimulation.

J S Yeomans·O Kofman·V McFarlane

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Abstract

Rats were implanted with stimulating electrodes in the lateral hypothalamus, and cannulae for chemical injections in the ventral tegmentum. Injections of atropine, a muscarinic antagonist, increased thresholds for self-stimulation in a dose-dependent fashion, without slowing bar pressing rates. Thresholds increased less for a self-stimulation site contralateral to the atropine injection. In a conditioned place preference test, the rats preferred compartments in which they received carbachol, a cholinergic agonist. Muscarinic receptors in ventral tegmentum therefore seem critical for medial forebrain bundle (MFB) reward. The possible cholinergic cells of origin are discussed.

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Animals Atropine Brain Mapping Carbachol Cholinergic Fibers Hypothalamic Area, Lateral Male Medial Forebrain Bundle Neural Pathways Rats Receptors, Muscarinic Reward Self Stimulation Journal Article Research Support, Non-U.S. Gov't

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J S Yeomans, O Kofman, V McFarlane. 1985-03-11. Cholinergic involvement in lateral hypothalamic rewarding brain stimulation.. https://doi.org/10.1016/0006-8993(85)90508-6

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