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Shaping human brain development and vulnerability through alternative splicing.

Francisco Aya·Juan Valcárcel
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Abstract

Alternative splicing contributes to shaping lineage-specific gene expression and phenotypes. In this issue of Cell Genomics, Recinos, Bao, Wang, et al.1 report that the balance between splicing isoforms of the microtubule-associated protein Tau in the brain is differentially regulated among primates by the RNA-binding protein MBNL2, with consequences for protein aggregation and neurodegeneration in humans.

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HumansAlternative SplicingBrainAnimalsRNA-Binding Proteinstau ProteinsProtein IsoformsJournal Article

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Francisco Aya, Juan Valcárcel. 2024-06-12. Shaping human brain development and vulnerability through alternative splicing.. https://doi.org/10.1016/j.xgen.2024.100584

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