Malignant hyperthermia: molecular defects in membrane permeability.

K S Cheah; A M Cheah

doi:10.1007/bf02007707

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Malignant hyperthermia: molecular defects in membrane permeability.

K S Cheah·A M Cheah

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Abstract

Malignant hyperthermia (MH), a genetically inherited disorder of skeletal muscle, is due to molecular defect in membrane permeability. The alteration in membrane permeability is suggested to be due to enhanced phospholipase A2 activity which is responsible for the increased level in sarcoplasmic Ca2+. The excess Ca2+ is responsible for muscle hyper-rigidity and enhanced rate of glycolysis, resulting in a rapid rate of lactic acid production and a low pH in MH muscle.

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Animals Calcium Cell Compartmentation Humans Malignant Hyperthermia Mitochondria, Muscle Muscle Contraction Muscles Permeability Phospholipases A Phospholipases A2 Sarcolemma Sarcoplasmic Reticulum Swine Journal Article Review

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K S Cheah, A M Cheah. 1985-05-15. Malignant hyperthermia: molecular defects in membrane permeability.. https://doi.org/10.1007/bf02007707

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