PubMed · 3892393
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J W Pratt. 1985. Look after yourself.. https://pubmed.ncbi.nlm.nih.gov/3892393/
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BACKGROUND AND OBJECTIVES: Clinical chemistry is an important component of the diagnosis of many conditions, and advances in laboratory science have brought many new diagnostic tools to the intensive care unit clinician, including new biomarkers of cardiac injury like troponin T and I. Interpretation of these clinical laboratory results requires knowledge of the performance of these tests. SETTING AND PATIENTS: This article reviews the interpretation and performance of diagnostic markers of myocardial injury in patients with diverse clinical conditions of interest to critical care practitioners. CONCLUSIONS: Cardiac troponin I and T, regulatory components of the contractile apparatus, are sensitive indicators of myocardial injury and have become central to the diagnosis of myocardial infarction. The troponins are also released in a number of clinical situations in which thrombotic complications of coronary artery disease and resultant acute myocardial infarction have not occurred. These situations include conditions like pulmonary embolism, sepsis, myocarditis, and acute stroke. Elevated troponins in these conditions are thought to emanate from injured myocardial cells and, in most circumstances, have been associated with adverse outcomes. Practitioners should be mindful of the wide spectrum of diseases that may result in elevated troponin when interpreting these measurements.
The 18th FIFA Soccer World Cup 2006 in Germany enthused millions of people worldwide, but only little is known about the association of such an event with cardiovascular events. Modest physical activity is known to reduce the cardiovascular risk significantly. On the other hand, vigorous physical activity and emotional strain increase the cardiovascular risk and the incidence of cardiovascular events likely due to an increased sympathetic tone with consecutive catecholamine stimulation of the heart. Few reviews and case-reports are dealing with the risk of physical activity in cardiovascular high-risk patients or athletes with congenital heart diseases (e.g. hypertrophic obstructive cardiomyopathy), but the impact of highly competitive events on cardiovascular events, especially in spectators were rarely addressed. Thus, the increased risk of cardiovascular events in players and spectators were addressed in this review with respect to various soccer matches and tournaments, such as the FIFA World Cup.
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