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PubMed · 38929

Drugs for inhibition of premature labor.

J R Niebyl
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Abstract

Effective inhibition of premature labor depends on prompt initiation of treatment. The author discusses factors initiating parturition, and the benefits and risks for mother and child of administration of alcohol, beta adrenergic agents, magnesium sulfate, and other agents that may counteract them.

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Adrenergic beta-AgonistsAnimalsEthanolFemaleHumansIndomethacinLabor, ObstetricMagnesium SulfateObstetric Labor, PrematurePregnancyProstaglandin AntagonistsUterusJournal ArticleReview

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J R Niebyl. 1979. Drugs for inhibition of premature labor.. https://pubmed.ncbi.nlm.nih.gov/38929/

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PubMed1979

In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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