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PubMed · 389842

Parapsoriasis with hyper-IgE.

T F Downham·L B Savoy
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Abstract

A 56-year-old black man had generalized chronic dermatitis for two years before parapsoriasis en plaque (large type) with hyper-IgE (12,000-22,000 ng/ml) was diagnosed. Lymphocyte cultures showed decreased response to mitogens. Direct immunofluorescence of involved skin showed epidermal and dermal mast cells with bound IgE. Parapsoriasis with hyper-IgE may represent a form of "hypersensitive immunosurveillance" allowing a patient to reject a clone of malignant cells and retard transformation from a benign state (parapsoriasis) to a malignant state (mycosis fungoides).

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Fluorescent Antibody TechniqueHumansImmunoglobulin EImmunoglobulinsImmunologic TechniquesMaleMast CellsMiddle AgedParapsoriasisRosette FormationSkin TestsCase ReportsJournal Article

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BibTeXRIS

T F Downham, L B Savoy. 1979. Parapsoriasis with hyper-IgE.. https://doi.org/10.1111/j.1365-4362.1979.tb04684.x

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