pH-dependent processes in proteins.

J B Matthew; F R Gurd; B Garcia-Moreno; M A Flanagan; K L March; S J Shire

doi:10.3109/10409238509085133

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pH-dependent processes in proteins.

J B Matthew·F R Gurd·B Garcia-Moreno·M A Flanagan·K L March·S J Shire

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Abstract

Recent improvements in the understanding of electrostatic interactions in proteins serve as a focus for the general topic of pH-dependent processes in proteins. The general importance of pH-dependent processes is first set out in terms of hydrogen ion equilibria, stability, ligand interactions, assembly, dynamics, and events in related molecular systems. The development of various theoretical treatments includes various formalisms in addition to the solvent interface model developed by Shire et al. as an extension of the Tanford-Kirkwood treatment. A number of detailed applications of the model are presented and future potentialities are sketched.

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Animals Binding Sites Drug Stability Hemoglobins Humans Hydrogen-Ion Concentration Kinetics Macromolecular Substances Methods Models, Biological Models, Molecular Myoglobin Protein Binding Protein Conformation Proteins Thermodynamics Journal Article Review

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J B Matthew, F R Gurd, B Garcia-Moreno, M A Flanagan, K L March, S J Shire. 1985. pH-dependent processes in proteins.. https://doi.org/10.3109/10409238509085133

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