B-cell subsets: functional and structural characteristics.

C M Baum; J M Davie; J P McKearn

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PubMed · 3899512

B-cell subsets: functional and structural characteristics.

C M Baum·J M Davie·J P McKearn

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Abstract

The review will examine B-cell differentiation with an emphasis on B-cell subpopulations. We will begin with an analysis of current evidence concerning B-cell ontogeny. The development of the B-cell repertoire will be traced from stem cell to effector cells. The CBA/N mouse, which expresses an X-linked immunodeficiency, will serve as a basis for discussing the delineation of B cells into subpopulations. The CBA/N mouse provides evidence for distinct populations of B cells which can be differentiated by cell surface antigens as well as function. We intend to focus on the functional diversity of B-cell subpopulations and how they develop. The CBA/N mouse is not the only evidence for distinct B cell subpopulations and we will attempt to organize these data into a coherent story of B-cell subsets.

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Animals Antibodies Antigens, Surface B-Lymphocytes Cell Differentiation Cell Membrane Immune System Diseases Immunoglobulin G Mice Mice, Inbred CBA Organ Specificity Rats Receptors, Antigen, B-Cell Sex Chromosome Aberrations T-Lymphocytes X Chromosome Journal Article Review

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C M Baum, J M Davie, J P McKearn. 1985. B-cell subsets: functional and structural characteristics.. https://pubmed.ncbi.nlm.nih.gov/3899512/

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