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DNA methylation and CpG suppression.

D N Cooper·S Gerber-Huber
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Abstract

Cytosine methylation in vertebrate genomes occurs predominantly at the dinucleotide CpG. This dinucleotide is deficient in vertebrate DNA, an observation which has hitherto been explained by passive deamination of S-methylcytosine to thymidine. Since the frequency and distribution of CpG may prove to be a useful indirect means to study the function of DNA methylation, it is of interest that the observed 'CpG suppression' is less apparent within and around coding sequences. A variety of different mechanisms now appear to be responsible for maintaining a relatively high CpG level in these regions despite the apparent attendant disadvantage of mutation.

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AnimalsBase SequenceCytidine MonophosphateCytosine NucleotidesDNADNA (Cytosine-5-)-MethyltransferasesDinucleoside PhosphatesGenesGuanosineHumansMethylationSuppression, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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D N Cooper, S Gerber-Huber. 1985. DNA methylation and CpG suppression.. https://doi.org/10.1016/0045-6039(85)90488-9

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