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PubMed · 3911486

Defibrinogenation with benzoyl-batroxobin.

F Markwardt·M Paintz·M Richter·J Stürzebecher
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Abstract

The B. moojeni thrombic protease, batroxobin, was acylated by 4-amidinophenyl benzoate at the active site serine hydroxyl. From the enzymatically inactive benzoyl-batroxobin, batroxobin is generated with a half-life of deacylation of about one hour. The clotting activity of benzoyl-batroxobin in plasma is recovered with deacylation. The effects of batroxobin and benzoyl-batroxobin were studied following intravenous injection in rats. Compared to defibrinogenation with batroxobin, that obtained with benzoyl-batroxobin was much retarded. Batroxobin caused microthrombosis initially, which did not develop upon injection of benzoyl-batroxobin in equivalent doses.

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AcylationBatroxobinBinding SitesBlood CoagulationElapid VenomsFibrinogenHalf-LifeHumansKineticsPeptide HydrolasesJournal Article

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F Markwardt, M Paintz, M Richter, J Stürzebecher. 1985-10-01. Defibrinogenation with benzoyl-batroxobin.. https://doi.org/10.1016/0049-3848(85)90348-2

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