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Conformational changes in DNA and soft modes.

K V Devi Prasad·E W Prohofsky
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Abstract

In this paper we explore the applicability of the soft mode approach to study the conformational transitions of DNA. It is believed that the A-B conformation change is a first order transition. Soft mode theories only apply to the initial stages of a first order transition. However the mode softening in such a case can be the initiating factor which ultimately leads to the transition. The first order transition is, then, a breakdown of what otherwise would have been a true second order transition. The mode softening is causally connected to onset of the transition. We use the eigenvectors obtained from lattice dynamics calculations to identify the softmode. We use the eigenvector projections to form a force constant matrix that is required to drive a mode soft. We explore the methods by which this force constant matrix can be formed. We suggest that the breaking of specific "water bridges" between phosphate groups in the two single strands can drive the conformation change.

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DNAModels, ChemicalNucleic Acid ConformationThermodynamicsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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BibTeXRIS

K V Devi Prasad, E W Prohofsky. 1985. Conformational changes in DNA and soft modes.. https://doi.org/10.1080/07391102.1985.10508443

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