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Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

B S Emanuel·L A Cannizzaro·I Magrath·Y Tsujimoto·P C Nowell·C M Croce
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Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.

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Burkitt LymphomaChromosomes, Human, 21-22 and YGenetic LinkageHumansImmunoglobulin Constant RegionsImmunoglobulin Light ChainsImmunoglobulin Variable RegionImmunoglobulin lambda-ChainsImmunoglobulinsNucleic Acid HybridizationTranslocation, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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B S Emanuel, L A Cannizzaro, I Magrath, Y Tsujimoto, P C Nowell, C M Croce. 1985-01-25. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.. https://doi.org/10.1093/nar%2F13.2.381

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