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PubMed · 3928958

Evidence for an anticomplementary factor associated with human bone marrow cells.

A P Gee·K M Bruce·T D Morris·M D Boyle
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Abstract

Complement (C)-mediated lysis of antibody-sensitized sheep erythrocytes was inhibited by the addition of human bone marrow cells. The anticomplementary activity could be attributed to a soluble factor that was released from the bone marrow cells. This factor inhibited at an early stage in the C-cascade and showed the characteristics of a factor that accelerates decay of C2. The release of such a factor by bone marrow cells would present an obstacle to the use of antibody and C to purge tumor cells from bone marrow that is to be used for autologous transplantation.

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AnimalsBone MarrowBone Marrow TransplantationComplement Inactivator ProteinsComplement System ProteinsCytotoxicity, ImmunologicEdetic AcidErythrocytesHumansKineticsMiceMice, Inbred BALB CRabbitsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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A P Gee, K M Bruce, T D Morris, M D Boyle. 1985. Evidence for an anticomplementary factor associated with human bone marrow cells.. https://pubmed.ncbi.nlm.nih.gov/3928958/

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