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PubMed · 3930110

Interferon-gamma induces HLA-DR expression by thyroid epithelium.

I Todd·R Pujol-Borrell·L J Hammond·G F Bottazzo·M Feldmann
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Abstract

We recently showed that human thyroid epithelial cells, which are normally negative for HLA-DR molecules, express HLA-DR in thyroid autoimmunity. Furthermore, induction of HLA-DR on normal thyroid cells can be achieved by culture with plant lectins. We have now found that recombinant human interferon-gamma (IFN-gamma) induces expression of HLA-DR molecules on cultured human thyroid cells, whereas Namalva IFN-alpha, recombinant IFN-beta or recombinant interleukin-2 (IL-2) do not. All three IFN, but not IL-2, enhanced thyroid cell HLA-A,B,C expression. The results strongly implicate T cells (which are the source of IFN-gamma) in the aberrant induction of DR on thyroid epithelial cells which is proposed to be a central feature of the immunopathological processes leading to autoimmunity.

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Cells, CulturedDose-Response Relationship, DrugEpitheliumFluorescent Antibody TechniqueHLA AntigensHLA-A AntigensHLA-B AntigensHLA-C AntigensHLA-DR AntigensHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-2Thyroid GlandJournal ArticleResearch Support, Non-U.S. Gov't

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I Todd, R Pujol-Borrell, L J Hammond, G F Bottazzo, M Feldmann. 1985. Interferon-gamma induces HLA-DR expression by thyroid epithelium.. https://pubmed.ncbi.nlm.nih.gov/3930110/

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