Vitamin A and lung development.

F Chytil

PubMed · 3934635

Vitamin A and lung development.

Abstract

Several lines of evidence suggest that vitamin A is involved in lung development. They are: 1) Dietary deficiency of the fat-soluble vitamin A results in squamous metaplasia of the tracheal and bronchial epithelium. 2) Infants with vitamin A deficiency have a high incidence of respiratory problems. 3) Levels of two intracellular proteins binding specifically retinol (vitamin A alcohol) and retinoic acid (vitamin A acid) change dramatically during perinatal lung development. 4) Prematurely born infants hospitalized for respiratory problems have low serum concentrations of retinol and retinol-binding protein. 5) Postnatal supply of vitamin A by parenteral alimentation may not be adequate, as large quantities of vitamin A are absorbed by the tubing. Careful assessment of vitamin A status in postnatal nutritional management of premature infants is desirable.

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Cell Differentiation Female Humans Infant, Newborn Infant, Premature Liver Lung Maternal-Fetal Exchange Parenteral Nutrition Pregnancy Retinol-Binding Proteins Vitamin A Vitamin A Deficiency Journal Article Research Support, U.S. Gov't, P.H.S.

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F Chytil. Vitamin A and lung development.. https://pubmed.ncbi.nlm.nih.gov/3934635/

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