Increased actin nucleating activity in tumorigenic cells.

R L Tellam; M R Banyard

doi:10.1016/0006-291x(86)90389-x

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Increased actin nucleating activity in tumorigenic cells.

R L Tellam·M R Banyard

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Abstract

The kinetics of actin polymerization has been used to quantitate the relative levels of actin nucleating activity in extracts from a number of related tumorigenic and non-tumorigenic cells. The level of nucleating activity was significantly elevated in the tumorigenic compared with the non-tumorigenic cell extracts whether the results were expressed on the basis of per protein (2-3 fold increase) or per total endogenous cellular actin (3-4 fold increase). It is concluded that this activity is probably due to an actin filament capping/severing regulatory protein(s) and that this protein(s) may be, at least partially, responsible for the microfilament disruption observed in transformed cells.

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R L Tellam, M R Banyard. 1986-02-13. Increased actin nucleating activity in tumorigenic cells.. https://doi.org/10.1016/0006-291x(86)90389-x

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