Systemic focal epileptogenesis.

M P Remler; W H Marcussen

doi:10.1111/j.1528-1157.1986.tb03498.x

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Systemic focal epileptogenesis.

M P Remler·W H Marcussen

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Abstract

Rats that receive radiation to 0.25 cc of one cerebral hemisphere are clinically and electroencephalographically normal until there is a breakdown of the blood-brain barrier (BBB) at 3 to 6 months postradiation. This BBB lesion can be detected by transient focal seizure activity produced by the BBB-excluded systemic convulsant bicuculline methiodide. In two rats the seizure activity induced by this one injection was self-sustaining. In seven of 15 other rats tested, the subsequent administration of repeated 2 mg/kg injections created a chronic focus that continued to spike with great frequency for 3 weeks or more without further administration of any convulsant. In three of eight other rats, implanted minipumps delivering 180 micrograms/h of bicuculline methiodide produced self-sustaining epileptic activity.

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Animals Bicuculline Blood-Brain Barrier Brain Disease Models, Animal Electroencephalography Epilepsy Kindling, Neurologic Rats Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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M P Remler, W H Marcussen. Systemic focal epileptogenesis.. https://doi.org/10.1111/j.1528-1157.1986.tb03498.x

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