Unsaturated platelet-activating factor: influence on aggregation, serotonin release and thromboxane synthesis of human thrombocytes.

R Korth; H Riess; G Brehm; E Hiller

doi:10.1016/0049-3848(86)90367-1

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Unsaturated platelet-activating factor: influence on aggregation, serotonin release and thromboxane synthesis of human thrombocytes.

R Korth·H Riess·G Brehm·E Hiller

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Abstract

Unsaturated platelet-activating factor (paf-acether) aggregated thrombocytes of healthy male volunteers like saturated paf-acether. Unsaturated paf-acether released serotonin in the presence of imipramine. Within one minute the release increased depending on the concentrations of unsaturated paf-acether up to 45% of the serotonin. Human thrombocytes synthesized only a small amount of thromboxane B2 (TXB2) after aggregation induced by unsaturated paf-acether. Unsaturated paf-acether prevented the binding of radiolabelled saturated paf-acether to intact washed thrombocytes in the same extent as saturated paf-acether.

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Blood Platelets Clonidine Humans In Vitro Techniques Male Platelet Activating Factor Platelet Aggregation Serotonin Structure-Activity Relationship Thromboxane B2 Journal Article Research Support, Non-U.S. Gov't

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R Korth, H Riess, G Brehm, E Hiller. 1986-03-01. Unsaturated platelet-activating factor: influence on aggregation, serotonin release and thromboxane synthesis of human thrombocytes.. https://doi.org/10.1016/0049-3848(86)90367-1

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