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PubMed · 3974944

Cholinergic and non-cholinergic septohippocampal pathways.

B H Wainer·A I Levey·D B Rye·M M Mesulam·E J Mufson
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Abstract

Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

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AcetylcholinesteraseAnimalsCholine O-AcetyltransferaseCholinergic FibersHippocampusMaleNeural PathwaysRatsRats, Inbred StrainsSeptum PellucidumJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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B H Wainer, A I Levey, D B Rye, M M Mesulam, E J Mufson. 1985-02-28. Cholinergic and non-cholinergic septohippocampal pathways.. https://doi.org/10.1016/s0304-3940(85)80116-6

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