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Apomorphine increases ethanol discrimination.

M D Schechter
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Abstract

Rats were trained to discriminate between the stimulus properties of 600 mg/kg ethanol and saline in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance with lower ethanol doses and analysis of the dose-response curve indicated an ED50 of 372 mg/kg. Pretreatment with 0.16 mg/kg apomorphine produced increased discriminative performance at each ethanol dose and the combination generated a dose-response curve parallel to ethanol administered alone with an ED50 of 232 mg/kg. This significant shift to the left of the ethanol dose-response curve after apomorphine administration is discussed in relation to dopaminergic neuronal systems and the clinical use of apomorphine alcoholics.

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AnimalsApomorphineDiscrimination, PsychologicalDose-Response Relationship, DrugEthanolMaleRatsRats, Inbred StrainsReceptors, DopamineJournal Article

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M D Schechter. 1985. Apomorphine increases ethanol discrimination.. https://doi.org/10.1016/0091-3057(85)90374-0

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