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Correlation between immunosuppressive activity and translation regulatory activity.

K C Wang·J Dougherty·S Lee·G M Iverson·R K Gershon
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Abstract

An immunoglobulin negative material from the eluate of an anti-idiotype immunosorbent column [1] exhibited potent immunosuppressive activity. This material also inhibited the translation of globin mRNA in a cell-free reticulocyte lysate system. The translation inhibitory activity of this material was not attributable to nucleases which were separable by a blue-dextran agarose column. Further correlation between immunosuppressive activity and translation inhibitory activity was observed when GTP or GTP analogue was included in experimental systems. These results suggest that the immunosuppressive factor (or factors) may contain a translation inhibitory factor. The biochemical mechanism of immunosuppression is discussed.

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AnimalsGlobinsGuanosine TriphosphateImmune ToleranceImmunoglobulin IdiotypesImmunosuppressive AgentsIn Vitro TechniquesMaleMiceMice, Inbred C57BLProtein BiosynthesisRNA, MessengerComparative StudyJournal Article

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K C Wang, J Dougherty, S Lee, G M Iverson, R K Gershon. 1985. Correlation between immunosuppressive activity and translation regulatory activity.. https://doi.org/10.1016/0165-2478(85)90022-7

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