PubMed · 399094
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M S Rosman, W P Jackson. 1979-12-08. The artificial beta cell.. https://pubmed.ncbi.nlm.nih.gov/399094/
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In 36 treated diabetics (15 with insulin, 21 with oral hypoglycaemic agents) without any detectable arterial atheromatous lesion, there was a negative correlation between the filtrability of red cells and blood glucose levels (r = - 0.60) on the one hand and, secondly, glycosylated haemoglobin levels (r = - 0.40). In 17 insulindependents diabetics connected to an artificial pancreas, normalisation of blood glucose was accompanied by a concomitant increase in the filtrability of red cells, and improvement of spontaneous platelet agregation. Good control of diabetes would thus appear to be necessary to reduce the incidence of microangiopathy.
Reproducible and reliable quantitative glucose determinations in physiological solutions of saline can be obtained by using platinum powder incorporated in a thin plastic layer on a platinum wire as the test microelectrode, while applying analytic and regenerative pulses of alternating voltage of +/- 1 V (sce). The results are the beginning of further investigations leading to continuous determinations of glucose concentration in body fluids.
The artificial endocrine pancreas or artificial beta cell, consists of a continuous blood glucose monitoring system, a computered set-up which responds to glycemia and the hormone delivery system. This system provides a technique which can completely normalize blood glucose concentration in diabetic patients, during both food assumption and after. This paper deals with the characteristics of the artificial beta cell, its possible applications and its limits.