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Systemic reactions associated with polyisocyanate exposure.

J Nielsen·C Sangö·G Winroth·T Hallberg·S Skerfving
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Abstract

A spray-painter suffered attacks of chills, fever, general malaise, dyspnea and wheezing, headache, arthralgia, and leucocytosis a few hours after exposure to aerosols of varnishes containing two different polyisocyanates based upon monomers of hexamethylene or toluene diisocyanate. Immunologic studies revealed an increase in the serum immunoglobulin G level, but no specific antibodies against isocyanates conjugated to human serum albumin. The polyisocyanate level in the workroom air was high [a time-weighted average of 4.2 mg/m3, corresponding to 17 mumol NCO (isocyanate groups)/m3], the toluene diisocyanate monomer level being much lower (a time-weighted average of 0.03 mg/m3, corresponding to 0.3 mumol NCO/m3).

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J Nielsen, C Sangö, G Winroth, T Hallberg, S Skerfving. 1985. Systemic reactions associated with polyisocyanate exposure.. https://doi.org/10.5271/sjweh.2253

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