Ia antigen expression on the developing mouse embryo and placenta.

E J Jenkinson; R F Searle

doi:10.1016/0165-0378(79)90024-x

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Ia antigen expression on the developing mouse embryo and placenta.

E J Jenkinson·R F Searle

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Abstract

The expression of I region controlled antigens on the mouse embryo and placenta has been investigated using immuno-peroxidase labelling and a mixed haemadsorption assay. The results indicate that Ia antigens are absent from selected pre- and post-implantation embryonic and trophoblastic tissues and from the trophoblast of the definitive placenta. In contrast, cells derived from the peri-placental maternal decidual tissues are Ia antigen-positive. The findings are discussed in relation to the allograft status of the conceptus and the identity and functional significance of the Ia-bearing maternal cells at the foeto-maternal interface.

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Animals Embryo, Mammalian Female Hemadsorption Histocompatibility Antigens Class II Immunoenzyme Techniques Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Placenta Pregnancy Receptors, Antigen, B-Cell Receptors, Fc Rosette Formation Journal Article

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E J Jenkinson, R F Searle. Ia antigen expression on the developing mouse embryo and placenta.. https://doi.org/10.1016/0165-0378(79)90024-x

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