Interaction between bisantrene and radiation.

E Hernandez; N B Rosenshein

doi:10.1016/0360-3016(85)90256-1

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Interaction between bisantrene and radiation.

E Hernandez·N B Rosenshein

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Abstract

The interaction between Bisantrene, a new anthracene derivative, and radiation was studied in vitro. Chinese hamster lung (V-79-171) cells grown as monolayers were exposed to three different concentrations (0.4 mcg/ml, 2 mcg/ml, 10 mcg/ml) of Bisantrene for 120 min. during their exponential growth phase. Immediately after drug exposure, the cells were irradiated with escalating doses of radiation (100-1200 rad). Isoeffect curves (99% cell kill) were calculated using dose-survival curves generated for each modality. Curve I assumed that the agents act by independent mechanisms; Curve II assumed that the agents act by a similar mechanism. The dose combinations of the two modalities producing a 99% kill were plotted against the calculated isoeffect curves. The experimental points were found to lie along the calculated lines. Pre-treatment with Bisantrene prior to radiation resulted in an additive effect, similar to that reported with Adriamycin.

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Animals Anthracenes Antibiotics, Antineoplastic Cell Line Cell Survival Cricetinae Cricetulus Dose-Response Relationship, Drug Dose-Response Relationship, Radiation In Vitro Techniques Journal Article Research Support, Non-U.S. Gov't

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E Hernandez, N B Rosenshein. 1985. Interaction between bisantrene and radiation.. https://doi.org/10.1016/0360-3016(85)90256-1

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