Ciamexone--a new highly selective immunosuppressive compound.

U Bicker; W Pahlke

doi:10.3109/08923978509026474

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PubMed · 4008940

Ciamexone--a new highly selective immunosuppressive compound.

U Bicker·W Pahlke

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Abstract

A local graft versus host reaction between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir). In this local mixed lymphocyte reaction mainly T-helper cells and B-cells are involved. An induction of a delayed type hypersensitivity reaction with oxazolon significantly decreases the local graft versus host reaction. Cyclosporin A depresses the local graft versus host reaction and the delayed type hypersensitivity in mice whereas Ciamexone, a 2-cyanaziridine derivative, very selectively only suppresses the local graft versus host reaction and increases the delayed type hypersensitivity.

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Animals Aziridines Azirines Cyclosporins Female Graft vs Host Reaction Hypersensitivity, Delayed Immunosuppressive Agents Lymph Nodes Lymphocyte Activation Mice Mice, Inbred Strains Oxazolone Journal Article

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U Bicker, W Pahlke. 1985. Ciamexone--a new highly selective immunosuppressive compound.. https://doi.org/10.3109/08923978509026474

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