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MIF as an oncogenic driver of low-heterogeneity melanomas.

Thuy T Tran·Gabriela Athziri Sánchez-Zuno·Rajan P Kulkarni·Harriet M Kluger·Richard Bucala
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Abstract

Identifying targets involved in tumor evolution and immune escape is an active area of research in oncology. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory cytokine that promotes transformed cell proliferation and survival, and generates a tumor-permissive immune landscape of immunosuppressive myeloid and T cells. Shvefel and colleagues have identified a key role for MIF in tumor progression in melanoma clones with low tumor heterogeneity. These findings provide important insights into the potential therapeutic utility of MIF antagonists and support ongoing research to utilize MIF pathway inhibitors for improved therapeutic outcomes.

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AnimalsHumansCarcinogenesisIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMelanomaOncogenesD‐dopachrome tautomeraseimmune resistancemacrophage migration inhibitory factormelanomatumor heterogeneitytumor‐associated macrophageJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.

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Thuy T Tran, Gabriela Athziri Sánchez-Zuno, Rajan P Kulkarni, Harriet M Kluger, Richard Bucala. 2025-03-25. MIF as an oncogenic driver of low-heterogeneity melanomas.. https://doi.org/10.1002/1878-0261.70031

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