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PubMed · 40138

Stimulation of beta-adrenoceptors by dobutamine in the guinea-pig atrium and tracheal chain.

J Wagner·H J Schümann
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Adrenergic beta-AgonistsAirway ResistanceAnimalsCatecholaminesDobutamineGuinea PigsHeartHeart RateIn Vitro TechniquesIsoproterenolMaleTerbutalineTracheaJournal Article

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J Wagner, H J Schümann. 1979. Stimulation of beta-adrenoceptors by dobutamine in the guinea-pig atrium and tracheal chain.. https://doi.org/10.1007/bf00499714

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PubMed1979

In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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