A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.

Nissim Benvenisty; Jonathan S Draper; Paul J Gokhale; Lyn Healy; Zoe Hewitt; Deborah Hursh; Adam Hodgson; Tenneille E Ludwig; Nancy Mah; Sarah E McClelland; Milena Mennecozzi; Florian T Merkle; Joanne C Mountford; Martin Pera; Alessandro Prigione; Tristan A Rodriguez; Andrea Rossi; Foad J Rouhani; Kourosh Saeb-Parsy; Lucia Selfa Aspiroz; Nika Shakiba; Claudia Spits; Peter D Tonge; Ivana Barbaric

doi:10.1016/j.stem.2025.03.003

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A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.

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Abstract

Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

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Humans Pluripotent Stem Cells Cell- and Tissue-Based Therapy Genetic Variation Journal Article Research Support, Non-U.S. Gov't

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Nissim Benvenisty, Jonathan S Draper, Paul J Gokhale, Lyn Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille E Ludwig, Nancy Mah, Sarah E McClelland, Milena Mennecozzi, Florian T Merkle, Joanne C Mountford, Martin Pera, Alessandro Prigione, Tristan A Rodriguez, Andrea Rossi, Foad J Rouhani, Kourosh Saeb-Parsy, Lucia Selfa Aspiroz, Nika Shakiba, Claudia Spits, Peter D Tonge, Ivana Barbaric. 2025-04-03. A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.. https://doi.org/10.1016/j.stem.2025.03.003

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