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PubMed · 4020248

Ventricular myocardial catecholamines in primates.

G L Pierpont·E G DeMaster·S Reynolds·J Pederson·J N Cohn
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Abstract

We report myocardial catecholamine levels in primate ventricles assayed by high-pressure liquid chromatography with electrochemical detection. The norepinephrine content of the left ventricles of 11 monkeys (four rhesus and seven cynomolgus) was 1391 +/- 362 ng/gm (+/-SD) with a definite gradient from base (highest) to apex (lowest concentration). Dopamine and epinephrine were present in much lower concentrations (51.8 +/- 24.5 ng/gm and 59.2 +/- 20.0 ng/gm, respectively), but were similarly distributed throughout the left ventricle. There was considerable variation in norepinephrine concentration between animals, but the dopamine/norepinephrine ratio was very consistent within a given animal, averaging 3.7% +/- 1.4%. These values are probably indicative of what normal concentrations of catecholamines are likely to be in humans, and provide a basis for interpretation of results obtained in disease studies.

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AnimalsCatecholaminesChromatography, High Pressure LiquidDopamineElectrochemistryEpinephrineFemaleHeart SeptumHeart VentriclesMacaca fascicularisMacaca mulattaMaleNorepinephrineJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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G L Pierpont, E G DeMaster, S Reynolds, J Pederson, J N Cohn. 1985. Ventricular myocardial catecholamines in primates.. https://pubmed.ncbi.nlm.nih.gov/4020248/

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