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PubMed · 402698

Immunoglobulin quantitation and characterization as a diagnostic tool.

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Bence Jones Protein Blood Protein Electrophoresis Dysgammaglobulinemia Humans Hypergammaglobulinemia Immunodiffusion Immunoelectrophoresis Immunoglobulin G Immunoglobulin Light Chains Immunoglobulins Immunologic Deficiency Syndromes Multiple Myeloma Paraproteinemias Proteins Journal Article Review

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D S Gordon. 1977. Immunoglobulin quantitation and characterization as a diagnostic tool.. https://doi.org/10.1097/00007611-197702000-00038

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A case of plasma cell leukemia showing mostly pleomorphic plasma cells in the form of convoluted and multilobated nuclei with some having bilobed nuclei and internuclear bridges is being reported for its rarity of occurrence. Patient presented with congestive cardiac failure and features of nephropathy. There were no lytic lesions in the bone. Serum electrophoresis did not show any M-band while urine electrophoresis demonstrated Bence Jones protein confirming a light chain only type of myeloma. Patient is in remission 5 months after diagnosis. The significance of recognising such pleomorphic plasma cells is discussed.

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