PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 4032755

[590-S].

H Furue
View original source ↗Export metadata ↓

Abstract

590-S (1-phthalidyl-5-fluorouracil) is a derivative of 5-fluorouracil and shows a several characteristics in experimental studies. That is, good absorption from the intestine, high blood levels of 5-fluorouracil, its rapid clearance, low toxicities, excellent tumor inhibition and broad anticancer spectrum, etc. From preliminary studies and phase I studies, MTD is thought to be 750-800 mg/m2 in daily administration. Mild G.I. toxicities was encountered in a few cases. However, CNS toxicities were not experienced in any of our cases.

Explore related subjects

Administration, OralAdultAnimalsAnorexiaAntineoplastic AgentsDrug Administration ScheduleDrug EvaluationFemaleFluorouracilHumansLeukemia, ExperimentalLiver Neoplasms, ExperimentalMaleMiceMiddle AgedNauseaNeoplasms, ExperimentalRabbitsRatsSarcoma, ExperimentalStomach NeoplasmsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H Furue. 1985. [590-S].. https://pubmed.ncbi.nlm.nih.gov/4032755/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Adjuvanted oral vaccines should not induce allergic responses to dietary antigens.

Oral vaccines may contain adjuvants which might elicit allergies against dietary proteins. Four antigens were used to measure such an effect--ovalbumin, soya bean protein, lactalbumin and gluten. Neither guinea pigs nor mice showed IgE responses after oral administration of adjuvanted vaccines containing lactalbumin and gluten. No IgE responses were detected in mice with any of these antigens after oral immunization, but, in the guinea pig, nine out of 18 animals reacted to either ovalbumin or soya bean protein and none reacted to lactalbumin and gluten. It is concluded that the risk of allergy induction against normal dietary proteins is low but such tests should be applied to potential adjuvanted oral vaccines to measure any possible contraindication, especially with atopic individuals.

Administration, Oral↗