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PubMed · 4034649

Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies.

L Szente·I Apostol·A Gerlóczy·J Szejtli
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Abstract

The dissolution and absorption of poorly water-soluble drugs from rectal suppositories can be enhanced by complexing these substances (e.g., essential oils, indomethacin) with beta-cyclodextrin. Preliminary in vivo studies showed, that the application of cyclodextrin complexes to suppositories, the same as to oral applications, resulted in an increased blood level.

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AbsorptionChemistry, PharmaceuticalCyclodextrinsDextrinsIndomethacinSolubilityStarchSuppositoriesX-Ray Diffractionbeta-CyclodextrinsJournal Article

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L Szente, I Apostol, A Gerlóczy, J Szejtli. 1985. Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies.. https://pubmed.ncbi.nlm.nih.gov/4034649/

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