Alternative explanations for normal variability in antithrombin-III levels.

E A Thompson; D T Bishop

doi:10.1080/03014468500007871

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Alternative explanations for normal variability in antithrombin-III levels.

E A Thompson·D T Bishop

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Abstract

Data collected in a study of ATIII deficiency also suggested familial variability of blood clotting times amongst genotypically normal individuals. A study of this variability under a variety of models demonstrates a clear age effect and within sibship similarity. There is also a clear parental effect, which could be either environmental or genetic. Even when parental effects are taken into account there remains some excess similarity between sibs, but the increase in log-likelihood provided by this component is no longer highly significant.

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Analysis of Variance Antithrombin III Antithrombin III Deficiency Female Genetic Variation Genotype Humans Male Models, Genetic Pedigree Reference Values Journal Article Research Support, U.S. Gov't, P.H.S.

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E A Thompson, D T Bishop. Alternative explanations for normal variability in antithrombin-III levels.. https://doi.org/10.1080/03014468500007871

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