Calcium antagonists--terminology, classification and comparison.

P A van Zwieten

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PubMed · 4039169

Calcium antagonists--terminology, classification and comparison.

P A van Zwieten

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Abstract

A survey is given of the terminology and classification of calcium antagonistic drugs. Calcium entry blockers are defined as drugs of which the major effect is the selective blockade of the slow inward current across the membrane, also under physiological conditions. Calcium overload blockers are defined as compounds which prevent the overloading of the cell with calcium under pathological, ischemic conditions. Both types of drugs should be considered as examples of different principles, although compounds which possess both properties simultaneously are known to exist. Furthermore, a comparison is made between the various groups of calcium entry blockers and calcium overload blockers, with respect to their chemical, pharmacological and therapeutic properties, including their organ specificity.

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Animals Calcium Channel Blockers Chemical Phenomena Chemistry Electrophysiology Humans In Vitro Techniques Muscle, Smooth, Vascular Organ Specificity Radioligand Assay Terminology as Topic Comparative Study Journal Article

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P A van Zwieten. 1985. Calcium antagonists--terminology, classification and comparison.. https://pubmed.ncbi.nlm.nih.gov/4039169/

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