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Chronic treatment of rats with D-600 causes a compensatory decrease in the calcium requirement for contractility of vascular smooth and cardiac muscles.

C C Pang·M C Sutter
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Abstract

We studied the effects of chronic hypotensive treatment of normotensive Wistar rats (NWR) with methoxyverapamil (D-600) and hydralazine on in vitro contractile response of aortic strips, portal vein strips, and Langendorff-perfused hearts in normal (2.5 mM) and low (0.2 mM) calcium (Ca). Portal vein strips from rats treated with D-600, compared with the same strips from control and hydralazine-treated rats, developed greater spontaneous contractile activity in normal Ca and retained greater responses to norepinephrine (NE) and 80 mM K in low Ca. Aortic strips from all three groups of rats retained similar responses to NE and K in low Ca. Hearts from D-600-treated rats produced less intraventricular pressure (IVP) to isoproterenol (ISO) than hearts from control and hydralazine-treated rats in normal Ca but greater IVP to ISO than hearts from the other two groups of rats in low Ca. Thus, chronic treatment of NWR with D-600 but not with hydralazine resulted in the reduction of Ca requirement for contractile activities of the portal vein and the myocardium.

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AnimalsBlood PressureCalciumGallopamilHeart RateHydralazineIn Vitro TechniquesIsoproterenolMaleMuscle ContractionMuscle, Smooth, VascularMyocardial ContractionNorepinephrinePortal VeinPotassiumRatsRats, Inbred SHRRats, Inbred StrainsVerapamilJournal ArticleResearch Support, Non-U.S. Gov't

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C C Pang, M C Sutter. 1985. Chronic treatment of rats with D-600 causes a compensatory decrease in the calcium requirement for contractility of vascular smooth and cardiac muscles.. https://doi.org/10.1139/y85-085

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