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PubMed · 4043361

[Effect of diazepam on interference processes].

I M Vinitskiĭ·N I Dubrovina·R Iu Il'iuchenok
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Abstract

It has been found in experimental behavioral interference during training in two conditioned reflexes, rapidly following each other, that intraperitoneal injection of diazepam (2 mg/kg) 30 min before training potentiates the inhibitory effect of the defensive reaction to the drinking one. Electrophysiological analysis of the modulating effect of amygdaloid stimulation on the peripheral signal transmission via the central gray matter has demonstrated that in the majority of the neurons, diazepam produced a longer and pronounced inhibition of the excitatory reactions in response to electrocutaneous stimulation after conditioning stimulation of the amygdaloid. The data obtained allow an assumption that inhibitory processes determined by the activity of the GABAergic amygdalofugal system underlie the interference interrelations.

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AmygdalaAnimalsAttentionBrainCognition DisordersConditioning, ClassicalDiazepamDrug Evaluation, PreclinicalElectric StimulationEscape ReactionInhibition, PsychologicalMaleMemoryMiceMice, Inbred BALB CNeuronsRatsRats, Inbred StrainsReaction TimeComparative StudyJournal Article

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I M Vinitskiĭ, N I Dubrovina, R Iu Il'iuchenok. [Effect of diazepam on interference processes].. https://pubmed.ncbi.nlm.nih.gov/4043361/

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