[Changes in stimulation analgesia during chronic morphine administration].

A S Morozova; E E Zvartau

PubMed · 4043366

[Changes in stimulation analgesia during chronic morphine administration].

Abstract

It has been shown in rat experiments that repeated administration of morphine produces tolerance to the effect of stimulation analgesia (SA). In the control group, the same stimulation of the periaqueductal gray matter (PGM) failed to produce tolerance. Naloxone (2 mg/kg i.p.) exerted a partially antagonistic influence on SA in the control group and did not affect the antinociceptive action of PGM stimulation in morphine-treated animals.

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Animals Dose-Response Relationship, Drug Drug Tolerance Electronarcosis Injections, Intraperitoneal Male Morphine Naloxone Pain Periaqueductal Gray Rats Sensory Thresholds Time Factors Comparative Study English Abstract Journal Article

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A S Morozova, E E Zvartau. [Changes in stimulation analgesia during chronic morphine administration].. https://pubmed.ncbi.nlm.nih.gov/4043366/

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