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PubMed · 40503

Brain tyrosine hydroxylase: kinetic properties and regulation of the activity.

M F Mineyeva·V S Kudrin·K S Rayevsky
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Abstract

Electrical stimulation of rat hypothalamic synaptosome suspensions produced activation of tyrosine hydroxylase due to increase of the affinity for tyrosine and 6,7-dimethyl-5,6,7,8-tetrahydropterine cofactor, decrease of the affinity for dopamine and enhancement of substrate inhibition. Cocaine (10(-7) - 10(-5) M) in vitro caused enzyme activation; when administered to animals systemically (0.5 mg/kg) the drug produced inhibition of hypothalamic tyrosine hydroxylase probably through a receptor-mediated feedback mechanism.

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AnimalsBrainCatecholaminesCocaineFeedbackHypothalamusReceptors, NeurotransmitterSynaptosomesTyrosine 3-MonooxygenaseJournal Article

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M F Mineyeva, V S Kudrin, K S Rayevsky. 1978. Brain tyrosine hydroxylase: kinetic properties and regulation of the activity.. https://pubmed.ncbi.nlm.nih.gov/40503/

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