Sarin intoxication elevates plasma pralidoxime.

M D Green; D E Jones; D E Hilmas

doi:10.1016/0378-4274(85)90004-9

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Sarin intoxication elevates plasma pralidoxime.

M D Green·D E Jones·D E Hilmas

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Abstract

Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication. Plasma levels after administration of 3.12 mg/kg of 2-PAM were elevated from a control mean of 6.18 micrograms/ml to a maximum of 13.78 micrograms/ml in animals given 557 micrograms/kg of sarin at 2 min after the injection of the therapeutic compounds. This suggests that pathophysiological changes following intoxication by potent inhibitors of cholinesterase result in a decrease in the rate and extent of distribution of therapeutic compounds. This effect is most likely a consequence of changes in cardiovascular functions influencing blood flow to various organs.

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Animals Guinea Pigs Organophosphate Poisoning Pralidoxime Compounds Regional Blood Flow Sarin Journal Article

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M D Green, D E Jones, D E Hilmas. 1985. Sarin intoxication elevates plasma pralidoxime.. https://doi.org/10.1016/0378-4274(85)90004-9

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