A general method of deriving the best binding site model consistent with experimental binding data.

J B Pedersen; S M Pedersen

doi:10.1016/0301-4622(85)80048-x

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A general method of deriving the best binding site model consistent with experimental binding data.

J B Pedersen·S M Pedersen

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Abstract

An analysis of binding data is presented which yields the best binding site model consistent with the experimental data. The analysis is applicable to homotropic binding and yields the number of independent sites, number of interacting sites (dimers and tetramers of sites), intrinsic association constants, and degree of interaction. The information is derived from the roots of a binding polynomial constructed by the fitted Adair constants.

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Binding Sites Biopolymers Mathematics Models, Biological Journal Article

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J B Pedersen, S M Pedersen. 1985. A general method of deriving the best binding site model consistent with experimental binding data.. https://doi.org/10.1016/0301-4622(85)80048-x

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