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Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study.

Weimin Xu·E Tian·Jun Wang·Xixi Yu·Zhaoqi Guo·Jingyu Chen·Sulin Zhang
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Abstract

BACKGROUND: Observational studies suggest the potential association between sleep traits and vertigo; however, causal evidence remains limited. OBJECTIVE: This study aimed to explore the relationship between genetically predicted sleep traits and vertigo with the Mendelian randomization (MR) method. METHODS: Instrumental variables for sleep traits (snoring, sleep duration, insomnia, daytime sleepiness, daytime napping, and chronotype) were adopted from genomewide association studies (GWAS) data of European ancestry from UK Biobank. The summary-level datasets of vertigo were retrieved from the GWAS of FinnGen. Inversevariance weighted (IVW) method was adopted as the main analysis. RESULTS: IVW analysis revealed a significant association between genetically predicted daytime napping (OR = 1.51, 95% CI =1.08-2.12, P = 0.016) and chronotype (OR = 1.13, 95% CI =1.01-1.26, P = 0.033), both of which were associated with an increased risk of vertigo. However, we did not find evidence for a causal effect of snoring, overall sleep duration, long sleep duration, short sleep duration, insomnia, and excessive daytime sleepiness on vertigo. No reverse causality was detected. CONCLUSION: Our findings suggest that abnormal sleep patterns may serve as risk factors for vertigo disorders and offer opportunities for the prevention and management of vertigo disorders.

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HumansVertigoMendelian Randomization AnalysisGenome-Wide Association StudySleepPolymorphism, Single NucleotideSleep DurationChronotypeGenetic Predisposition to DiseaseRisk FactorsSleep traitscausal relationshipgenetic associationmendelian randomizationrisk factorsvertigoJournal Article

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Weimin Xu, E Tian, Jun Wang, Xixi Yu, Zhaoqi Guo, Jingyu Chen, Sulin Zhang. 2026. Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study.. https://doi.org/10.2174/0115665240358943250612115854

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