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Multiple-hole approach to zero-order release.

W Y Kuu·S H Yalkowsky
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Abstract

We describe an approach to zero-order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero-order release is attained by using the proper density and configuration of holes on the surface of the device.

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Chemistry, PharmaceuticalDelayed-Action PreparationsDiffusionSolubilityJournal Article

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W Y Kuu, S H Yalkowsky. 1985. Multiple-hole approach to zero-order release.. https://doi.org/10.1002/jps.2600740904

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