A back-to-back zig-zag model for higher order chromatin structure.

L A Burgoyne

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PubMed · 4075844

A back-to-back zig-zag model for higher order chromatin structure.

L A Burgoyne

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Abstract

The evidence for the next level of chromatin structure above the 'zig-zag' is examined and a system of large, uncoiled, 'hair-pin' loops, folded until the zig-zags are back to back, is proposed as being more compatible with the evidence than coiling models. The loop model suggests a simple way for the base sequences on the DNA to control the higher order folding of chromatin, and is also strongly suggestive of a simple mechanism ensuring homologous alignment of nucleofilaments at synapse.

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Animals Chemical Phenomena Chemistry Chromatin DNA Humans Microscopy, Electron Models, Molecular Nucleosomes Protein Conformation Journal Article Research Support, Non-U.S. Gov't

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L A Burgoyne. 1985. A back-to-back zig-zag model for higher order chromatin structure.. https://pubmed.ncbi.nlm.nih.gov/4075844/

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