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American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.

Arsene Mekinian·Sophie Georgin-Lavialle·Marcela A Ferrada·Sinisa Savic·Matthew J Koster·Olivier Kosmider·Thibault Comont·Mael Heiblig·Juan I Arostegui·Annmarie Bosco·Rim Bourguiba·Katherine R Calvo·Catherine Cargo·Chiara Cattaneo·François Chasset·Henrique Coelho·Corrado Campochiaro·Francesca Crisafulli·Stephanie Ducharme-Benard·Raquel Faria·Franco Franceschini·Micol Frassi·Emma M Groarke·Carmelo Gurnari·Yervand Hakobyan·Yvan Jamilloux·Ciprian Jurcut·Yohei Kirino·Austin Kulasekararaj·Hiroyoshi Kunimoto·Lauren M Madigan·Heřman F Mann·Chiara Marvisi·Marcin Milchert·Sara Morais·Katja Sockel·Francesco Muratore·Hideaki Nakajima·Mrinal M Patnaik·Luísa Regadas·Marie Robin·Abraham Rutgers·Carlo Salvarani·Anthony M Sammel·Joerg Seebach·Pierre Sujobert·Alessandro Tomelleri·Geoffrey Urbanski·Frédéric Vandergheynst·Romana Vieira·David S Viswanatha·Ewa Więsik-Szewczyk·Elisa Diral·Benjamin Terrier·Bhavisha A Patel·Pierre Fenaux·Peter C Grayson·David B Beck·International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases
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Abstract

OBJECTIVE: Vacuoles E1 enzyme X-linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the UBA1 gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality. METHODS: Given the variability in disease presentation and the limited number of studies to date, no clinical documents currently exist to provide guidance to health care providers about the management of VEXAS. To address this gap, we formed an international multidisciplinary panel of VEXAS experts. RESULTS: Through formalized meetings and a voting process, the group developed consensus clinical guidance considerations for the management of VEXAS. These considerations offer practical advice on several key topics: (1) clinical features of VEXAS, (2) UBA1 screening methods, (3) the diagnosis of myelodysplastic syndromes (MDSs) in patients with VEXAS, and (4) prognosis and management. The aim is to provide expert guidance on which patients to test, how to test for VEXAS, how to approach MDS in the context of VEXAS, and considerations for management. CONCLUSION: This work marks the first formal international consensus guidance for VEXAS and is intended to be used as a resource for clinicians seeking to understand the disease and its management.

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HumansUbiquitin-Activating EnzymesMyelodysplastic SyndromesHereditary Autoinflammatory DiseasesMutationConsensusRheumatologySkin Diseases, GeneticJournal ArticlePractice Guideline

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Arsene Mekinian, Sophie Georgin-Lavialle, Marcela A Ferrada, Sinisa Savic, Matthew J Koster, Olivier Kosmider, Thibault Comont, Mael Heiblig, Juan I Arostegui, Annmarie Bosco, Rim Bourguiba, Katherine R Calvo, Catherine Cargo, Chiara Cattaneo, François Chasset, Henrique Coelho, Corrado Campochiaro, Francesca Crisafulli, Stephanie Ducharme-Benard, Raquel Faria, Franco Franceschini, Micol Frassi, Emma M Groarke, Carmelo Gurnari, Yervand Hakobyan, Yvan Jamilloux, Ciprian Jurcut, Yohei Kirino, Austin Kulasekararaj, Hiroyoshi Kunimoto, Lauren M Madigan, Heřman F Mann, Chiara Marvisi, Marcin Milchert, Sara Morais, Katja Sockel, Francesco Muratore, Hideaki Nakajima, Mrinal M Patnaik, Luísa Regadas, Marie Robin, Abraham Rutgers, Carlo Salvarani, Anthony M Sammel, Joerg Seebach, Pierre Sujobert, Alessandro Tomelleri, Geoffrey Urbanski, Frédéric Vandergheynst, Romana Vieira, David S Viswanatha, Ewa Więsik-Szewczyk, Elisa Diral, Benjamin Terrier, Bhavisha A Patel, Pierre Fenaux, Peter C Grayson, David B Beck, International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases. 2025-08-11. American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.. https://doi.org/10.1002/art.43287

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