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Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women.

Carlos J Toro-Huamanchumo·Abadi Kahsu Gebre·Tiago Pecanha·Craig Sale·Wai Lim·Elizabeth Byrnes·Ee Mun Lim·Simon Laws·Kun Zhu·Carl Schultz·Richard L Prince·Blossom Cm Stephan·Mario Siervo·Joshua R Lewis·Marc Sim
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Abstract

BACKGROUND: Elevated high-sensitivity cardiac troponin (hs-cTn) levels are linked with cardiovascular disease and cognitive impairment, both of which are strong risk factors for late-life dementia (LLD). This study examined the association between hs-cTnI levels below the sex-specific 99th percentile for myocardial injury and the incidence of LLD in older women. METHODS: 986 community-dwelling women aged &#x2265;70 years without prior LLD and with hs-cTnI <15.6&#x2009;ng/L (stratified into quartiles) were included from the Perth Longitudinal Study of Ageing Women. The primary outcome was incident LLD events, including LLD hospitalisation or death, over 14.5 years obtained from linked health records. Associations between hs-cTnI and LLD outcomes were explored using multivariable-adjusted Cox models, as part of restricted cubic splines. RESULTS: At baseline, participants' mean (&#xb1;SD) age was 75.2&#xb1;2.7 years. Over 14.5 years of follow-up, LLD events (n=174, 17.7%), hospitalisations (n=155, 15.7%) and deaths (n=68, 6.9%) were recorded. Compared with those in the lowest quartile (Q1, median 3.1&#x2009;ng/L), women in the highest quartile of hs-cTnI (Q4, median 7.3&#x2009;ng/L) had a greater risk of developing LLD-related events (adjusted HR: 1.88, 95%&#x2009;CI: 1.22 to 2.91), hospitalisation (adjusted HR: 1.65, 95%&#x2009;CI: 1.04 to 2.64) and death (adjusted HR: 2.27, 95%&#x2009;CI: 1.13 to 4.59), after adjusting for established cardiovascular and dementia risk factors, including apolipoprotein E (APOE) genotype. CONCLUSION: Among older women, hs-cTnI levels below the sex-specific 99th percentile for myocardial injury were associated with an increased risk of LLD events over 14.5 years. These findings suggest that hs-cTnI may identify older women at higher risk of LLD, capturing both cardiovascular and brain health vulnerability in older age. TRIAL REGISTRATION NUMBER: ACTRN12617000640303.

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HumansFemaleDementiaTroponin IAgedLongitudinal StudiesBiomarkersAgingIncidenceAged, 80 and overRisk FactorsAustraliaSex FactorsAge FactorsRisk AssessmentCardiovascular DiseasesCohort StudiesJournal ArticleResearch Support, Non-U.S. Gov't

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Carlos J Toro-Huamanchumo, Abadi Kahsu Gebre, Tiago Pecanha, Craig Sale, Wai Lim, Elizabeth Byrnes, Ee Mun Lim, Simon Laws, Kun Zhu, Carl Schultz, Richard L Prince, Blossom Cm Stephan, Mario Siervo, Joshua R Lewis, Marc Sim. 2026-09-11. Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women.. https://doi.org/10.1136/heartjnl-2025-326066

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