PubMed · 4104026
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W Schweisheimer. 1971. [Sim 1 - a practice patient without sensitivity].. https://pubmed.ncbi.nlm.nih.gov/4104026/
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This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.
The animation illustrates the recruitment, calcium-triggered exocytosis, and clathrin-mediated endocytosis of synaptic vesicles. The animation shows not only the proteins involved in synaptic vesicle fusion and recycling, but also changes in the lipid composition that are important for targeting of proteins to sites of membrane internalization. The animation would be useful in both neurobiology courses, but also any cell biology course that explores clathrin-mediated endocytic and calcium-regulated secretion events.
The animation illustrates one model for "kiss-and-run" or fast-track release of neurotransmitter through a calcium-triggered transient pore formed between the synaptic vesicle and plasma membrane. The vesicles remain attached to the plasma membrane throughout the cycle. The animation illustrates a role for SNARE proteins and dynamin in the formation and closure of the pore. The animation would be useful in both neurobiology courses, but also any cell biology course that explores calcium-regulated secretion events.