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PubMed · 4105103

IgE-mediated hypersensitivity.

J Pepys
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Cromolyn SodiumHistamine ReleaseHumansHypersensitivity, ImmediateImmunoglobulin ELymphoid TissueMast CellsMucous MembraneSkin Testsgamma-GlobulinsJournal Article

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J Pepys. 1971. IgE-mediated hypersensitivity.. https://doi.org/10.1042/cs041001pc

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Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome.

We report a case of hyperimmunoglobulin E syndrome (HIE) complicated by neutrophil deficiency which was successfully treated with oral administration of disodium cromoglycate. A 48-year-old Japanese man with HIE developed Streptococcus pneumoniae meningitis. Laboratory tests after the meningitis revealed persistent neutropenia (300-800/mm3) and defects of phagocytosis and bacterial killing by neutrophils. Administration of disodium cromoglycate was started, and neutrophil counts gradually increased to 1200-1600/mm3. The impaired neutrophil activities returned to normal. The patient improved clinically; during the 2-year treatment, he had only two brief episodes of the common cold. Disodium cromoglycate may have potential clinical use in the treatment of cases of HIE even with neutrophil deficiency.

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